The Capripoxvirus genus includes sheep pox virus (SPV), a contagious viral infection of small ruminants primarily affecting sheep.It is characterized by severe skin lesions, fever, diarrhea, difficulty breathing, pulmonary involvement, and death.This leads to enormous economic losses for sheep farmers.Recently, numerous cases of individual and mult
Epithelial-to-mesenchymal transition (EMT) in cancer cells facilitates tumor progression by promoting invasion and metastasis.Snail is a transcriptional factor that induces EMT, while P-glycoprotein (P-gp) is an efflux transporter involved in anticancer drug resistance, and P-gp efflux activity is stimulated in Snail-overexpressing lung cancer cell
Biological drug substance (DS) is often frozen to enhance storage stability, prolong shelf life, and increase flexibility during manufacturing.However, the freezing and thawing (F/T) of bulk DS at the manufacturing scale can impact product quality as a result of various critical conditions, including cryo-concentration during freezing, which are in
IntroductionPilonidal disease (PD) is a common infectious and inflammatory condition affecting the gluteal cleft and sacrococcygeal region.The optimal treatment for PD remains controversial.While the open Left Cup Holder technique reduces the number of relapses compared to minimally invasive approaches, it is associated with a longer healing time.R
Peptide-functionalized nanomedicine has emerged as a transformative approach in precision therapeutics and diagnostics, leveraging the specificity of peptides to enhance the performance of nanocarriers, including gold nanoparticles, polymeric nanoparticles, liposomes, mesoporous silica nanoparticles, and quantum dots.These systems enable targeted d